Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP9 | P55211 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28744455 | 0.80 | MAOA (0.39) | ALDH1A1MAOAMAOBCYP1A2AHR | |
| SCHEMBL9692443 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4EHPGD | |
| SCHEMBL11256569 | 0.74 | MAOA (0.41) | ALDH1A1MAOAMAOBCYP1A2AHR | |
| SCHEMBL1115175 | 0.73 | ALDH1A1 (0.41) | ALDH1A1MAOAMAOBCYP1A2POLB | |
| SCHEMBL21276097 | 0.73 | SIGMAR1 (0.47) | HTR2A | |
| SCHEMBL6561118 | 0.72 | KDM4E (0.41) | ALDH1A1KDM4EHPGDAVPR1A | |
| SCHEMBL28830167 | 0.72 | MAPT (0.47) | ALDH1A1KDM4EHPGDL3MBTL1POLB | |
| SCHEMBL2120401 | 0.72 | SMN1; SMN2 (0.35) | ALDH1A1MAOAMAOBCYP1A2L3MBTL1 | |
| SCHEMBL8645380 | 0.72 | KDM4E (0.41) | ALDH1A1KDM4EHPGDCYP1A2POLB | |
| SCHEMBL8794691 | 0.72 | TDP2 (0.46) | ALDH1A1KDM4EHPGDLMNATDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8310981-A | — | — | None | — | — | JP | disclosed |
| US-11649242-B2 | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators | FORMA THERAPEUTICS, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| EP-2871187-B1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | SNU R&DB FOUNDATION (KR) | 2017-09-20 | — | — | EP | disclosed |
| US-9745280-B2 | Compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient | SNU R&DB FOUNDATION (KR) | 2017-08-29 | — | — | US | disclosed |
| US-20160340331-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | SNU R&DB FOUNDATION (KR) | 2016-11-24 | — | — | US | disclosed |
| US-20150183797-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | SNU R&DB FOUNDATION (KR) | 2015-07-02 | — | — | US | disclosed |
| EP-2871187-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | SNU R&DB Foundation (KR) | 2015-05-13 | — | — | EP | disclosed |
| CN-101843908-B | Contrast agents for myocardial perfusion imaging | BRISTOL MYERS SQUIBB PHARMA CO | 2014-09-10 | — | — | CN | disclosed |
| US-8791111-B2 | Piperidine and piperazine derivatives | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8754097-B2 | Piperidine and piperazine derivatives | MERCK PATENT GMBH (DE) | 2014-06-17 | — | — | US | disclosed |
| US-20100222341-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HARTUNG (DE) | 2010-09-02 | — | — | US | disclosed |
| CN-1976728-A | Contrast agents for myocardial perfusion imaging | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2007-06-06 | — | — | CN | disclosed |
| WO-2002005830-A2 | EXTRACTS FROM CRASSULACEAN ACID METABOLISM (CAM) MECHANISM PLANTS AND USES THEREOF | KANE SHANTARAM GOVIND (IN) | 2002-01-24 | — | — | WO | disclosed |
| US-5756790-A | FROM KETONES | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-26 | — | — | US | disclosed |
| JP-H08310981-A | PRODUCTION OF OPTICALLY ACTIVE ALCOHOL | MITSUI PETROCHEM IND LTD | 1996-11-26 | — | — | JP | disclosed |
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5112855-A | Nootropic Agents | CIBA-GEIGY CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| US-4957928-A | NOOTROPIC AGENTS, COGNITION ACTIVATORS | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| EP-0322361-A2 | Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds | CIBA-GEIGY AG (CH) | 1989-06-28 | — | — | EP | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183797-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | HSP90AB1, HSP90AA1, HIF1AN | ALDH1A1 355/4885KDM4E 2649/4885HPGD 905/4885 |
| US-20100222341-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | CCND2, CCND1, TPD52L2 | ALDH1A1 389/4885KDM4E 1517/4885HPGD 195/4885 |
| US-11649242-B2 | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators | PDK1, PKM, PKLR | ALDH1A1 3741/4885KDM4E 1231/4885HPGD 1603/4885 |
| US-20160340331-A1 | NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | HSP90AB1, HSP90AA1, HSP90AB2P | ALDH1A1 963/4885KDM4E 2949/4885HPGD 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.