Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460737 | 0.89 | PPARG (0.40) | BRS3ALDH1A1MAPK1APLNRPPARG | |
| SCHEMBL8076004 | 0.84 | BRS3 (0.46) | BRS3AGTR1AGTR2 | |
| SCHEMBL8741233 | 0.80 | GCGR (0.32) | BRS3ADORA3ADORA2AADORA1PPARG | |
| SCHEMBL7325296 | 0.79 | PPARG (0.38) | BRS3ALDH1A1MAPK1APLNRPPARG | |
| SCHEMBL6534773 | 0.77 | BRS3 (0.54) | BRS3AGTR1AGTR2 | |
| SCHEMBL3459617 | 0.74 | ACHE (0.40) | BRS3ALDH1A1MAPK1APLNRPPARG | |
| SCHEMBL7050688 | 0.73 | AGTR1 (0.34) | BRS3PPARGAGTR1AGTR2PDE3B | |
| SCHEMBL9274853 | 0.69 | CYP19A1 (0.37) | XDHBRS3ALDH1A1MAPK1ADORA3 | |
| SCHEMBL5311279 | 0.67 | CYP1A2 (0.39) | XDHCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2692033 | 0.67 | CYP19A1 (0.50) | CYP1A2CYP2C9CYP2C19NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019048-A1 | USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS | Merck Sharp Dohme (Italia) S.P.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016437-A1 | USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS | MERCK SHARP DOHME (ITALIA) S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |