Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459604 | 0.95 | — | — | |
| SCHEMBL8072767 | 0.93 | FDPS (0.36) | FDPSALDH1A1TSHRFFAR3HDAC3 | |
| Ammonia Solution, Strong SCHEMBL28340659 | 0.93 | FDPS (0.36) | FDPSALDH1A1TSHRFFAR3HDAC3 | |
| SCHEMBL6624472 | 0.93 | FDPS (0.36) | FDPSALDH1A1TSHRFFAR3HDAC3 | |
| SCHEMBL7122285 | 0.81 | AKR1B1 (0.37) | ALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8074880 | 0.79 | FFAR3 (0.33) | FDPSTSHRFFAR3HDAC3HDAC1 | |
| SCHEMBL18095169 | 0.74 | — | — | |
| SCHEMBL8065098 | 0.73 | — | — | |
| SCHEMBL14762676 | 0.73 | FFAR3 (0.36) | FDPSALDH1A1TSHRFFAR3HDAC3 | |
| SCHEMBL11061354 | 0.72 | FFAR3 (0.35) | FDPSALDH1A1TSHRFFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840723-B1 | Salts of aliphatic alpha-hydroxy carboxylic acids and their preparation | ZINPRO CORP (US) | 2000-08-16 | — | — | EP | disclosed |