Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085101 | 0.94 | ALOX5 (0.52) | ALOX5MAPKAPK2ROCK2GSTP1KDR | |
| SCHEMBL8085131 | 0.93 | ALOX5 (0.51) | ALOX5MAPKAPK2ROCK2GSTP1KDR | |
| SCHEMBL8084959 | 0.91 | ALOX5 (0.47) | ALOX5MAPKAPK2ROCK2GSTP1KDR | |
| SCHEMBL8081908 | 0.91 | ALOX5 (0.49) | ALOX5MAPKAPK2ROCK2NQO2KDM4E | |
| SCHEMBL8086655 | 0.90 | ROCK2 (0.49) | ALOX5MAPKAPK2ROCK2KDRAURKA | |
| SCHEMBL8082235 | 0.90 | ALOX5 (0.48) | ALOX5MAPKAPK2ROCK2GSTP1KDR | |
| SCHEMBL8086679 | 0.90 | ALOX5 (0.48) | ALOX5MAPKAPK2ROCK2GSTP1KDR | |
| SCHEMBL8080761 | 0.87 | ALOX5 (0.48) | ALOX5MAPKAPK2ROCK2KDM4EALDH1A1 | |
| SCHEMBL8467392 | 0.87 | RXFP1 (0.52) | ALOX5MAPKAPK2ROCK2KDRGPR84 | |
| SCHEMBL8081224 | 0.86 | ALOX5 (0.53) | ALOX5GSTP1KDRAURKAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | claimed |
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |