Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084959 | 0.89 | ALOX5 (0.47) | RXFP1ALOX5GPR84KDRMAPKAPK2 | |
| SCHEMBL8072870 | 0.87 | ALOX5 (0.55) | ALDH1A1HPGDKDM4EALOX5GPR84 | |
| SCHEMBL8080761 | 0.84 | ALOX5 (0.48) | RXFP1ALDH1A1HPGDKDM4EALOX5 | |
| SCHEMBL8086655 | 0.83 | ROCK2 (0.49) | RXFP1ALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL8085101 | 0.82 | ALOX5 (0.52) | ALDH1A1HPGDKDM4EALOX5KDR | |
| SCHEMBL8081908 | 0.81 | ALOX5 (0.49) | KDM4EALOX5MAPKAPK2ROCK2 | |
| SCHEMBL8085131 | 0.81 | ALOX5 (0.51) | ALOX5POLBKDRMAPKAPK2ROCK2 | |
| SCHEMBL8467393 | 0.80 | ALOX5 (0.42) | ALOX5SLC22A12GPR84KDRMAPKAPK2 | |
| SCHEMBL8081224 | 0.79 | ALOX5 (0.53) | ALOX5KDR | |
| SCHEMBL8086679 | 0.78 | ALOX5 (0.48) | ALOX5KDRMAPKAPK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |