Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072870 | 0.91 | ALOX5 (0.55) | ALOX5MAPKAPK2NQO2PARP1ROCK2 | |
| SCHEMBL8080761 | 0.87 | ALOX5 (0.48) | ALOX5MAPKAPK2ROCK2KDM4ESMN1; SMN2 | |
| SCHEMBL8081224 | 0.86 | ALOX5 (0.53) | ALOX5EDNRB | |
| SCHEMBL8085101 | 0.85 | ALOX5 (0.52) | ALOX5MAPKAPK2NQO2ROCK2KDM4E | |
| SCHEMBL8084959 | 0.84 | ALOX5 (0.47) | ALOX5PIK3CDPIK3CBPIK3CGMAPKAPK2 | |
| SCHEMBL8085131 | 0.84 | ALOX5 (0.51) | ALOX5MAPKAPK2NQO2ROCK2KMT2A | |
| SCHEMBL8086655 | 0.84 | ROCK2 (0.49) | ALOX5MAPKAPK2ROCK2KDM4EMEN1 | |
| SCHEMBL8086679 | 0.81 | ALOX5 (0.48) | ALOX5MAPKAPK2NQO2ROCK2 | |
| SCHEMBL8082235 | 0.81 | ALOX5 (0.48) | ALOX5MAPKAPK2NQO2ROCK2 | |
| SCHEMBL8467392 | 0.81 | RXFP1 (0.52) | ALOX5MAPKAPK2ROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |