SCHEMBL7226876

SCHEMBL7226876

COc1cc(Cl)nc(C(=O)NS(=O)(=O)c2ccccc2Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 4/20 0.49
FLT4 P35916 4/20 0.49
KDR P35968 4/20 0.49
POLB P06746 1/20 0.46
LGALS8 O00214 1/20 0.45
LGALS3 P17931 1/20 0.45
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 2/20 0.41
CCR4 P51679 1/20 0.41
NPC1 O15118 1/20 0.41
HTT P42858 2/20 0.40
ALKBH2 Q6NS38 1/20 0.39
ALKBH3 Q96Q83 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 2/20 0.38
MAPT P10636 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7233649 0.91 CCR4 (0.47) FLT1FLT4KDRCCR4
SCHEMBL7236902 0.89 GCK (0.40) FLT1FLT4KDRKDM4ENPC1
SCHEMBL7226908 0.87 KMT2A (0.44) FLT1FLT4KDRALDH1A1KDM4E
SCHEMBL7235501 0.87 FLT1 (0.44) FLT1FLT4KDRLGALS8LGALS3
SCHEMBL7227157 0.86 ALDH1A1 (0.38) FLT1FLT4KDRALDH1A1KDM4E
SCHEMBL7235392 0.85 ALKBH2 (0.35) FLT1FLT4KDRKDM4EHTT
SCHEMBL7227192 0.84 FBP1 (0.51) ALKBH2ALKBH3
SCHEMBL7227318 0.81 ALDH1A1 (0.42) FLT1FLT4KDRALDH1A1KDM4E
SCHEMBL9192766 0.79 FLT1 (0.52) FLT1FLT4KDRPOLBLGALS8
SCHEMBL8074044 0.77 FLT1 (0.52) FLT1FLT4KDRPOLBLGALS8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6610853-B1 N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide KUREHA KAGAKU KOGYO K.K. (JP) 2003-08-26 US disclosed
EP-1069112-A1 N-(PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-01-17 EP disclosed