Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528103 | 0.81 | CYP3A4 (0.50) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8546392 | 0.77 | ADORA3 (0.53) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11775934 | 0.75 | CYP3A4 (0.53) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11799224 | 0.75 | CYP3A4 (0.65) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8569494 | 0.75 | MEN1 (0.56) | MEN1KMT2AALDH1A1POLBTSHR | |
| SCHEMBL28797295 | 0.74 | KDM4E (0.53) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28662473 | 0.73 | CYP3A4 (0.57) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7071011 | 0.72 | CYP3A4 (0.53) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11090058 | 0.72 | KDM4E (0.49) | CYP3A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8539340 | 0.71 | ALDH1A1 (0.52) | CYP3A4GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103721-A | TREATMENT OF STROKE ANOXIA; ANTIHYPERGLYCEMIC,-ISCHEMIC AND -EPILEPTIC AGENTS | ZENECA LIMITED (GB) | 2000-08-15 | — | — | US | disclosed |