Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.40 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.40 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10861354 | 0.81 | KDM4E (0.51) | ALDH1A1TSHRKDM4EMEN1KMT2A | |
| SCHEMBL8074157 | 0.81 | CYP3A4 (0.48) | CYP3A4ALDH1A1HSD17B10TSHRRHOA | |
| SCHEMBL1123696 | 0.76 | KDM4E (0.47) | ALDH1A1TSHRLCKMAP2K3MAP2K6 | |
| SCHEMBL8546392 | 0.74 | ADORA3 (0.53) | CYP3A4ALDH1A1HSD17B10TSHRSNCA | |
| SCHEMBL7706331 | 0.72 | LCK (0.51) | ALDH1A1HSD17B10TSHRLCKMAP2K3 | |
| SCHEMBL31371878 | 0.72 | LCK (0.51) | ALDH1A1HSD17B10TSHRLCKMAP2K3 | |
| SCHEMBL11775934 | 0.71 | CYP3A4 (0.53) | CYP3A4ALDH1A1HSD17B10TSHRRHOA | |
| SCHEMBL9525498 | 0.71 | LCK (0.50) | ALDH1A1LCKMAP2K3MAP2K6BTK | |
| SCHEMBL11799224 | 0.71 | CYP3A4 (0.65) | CYP3A4ALDH1A1HSD17B10TSHRRHOA | |
| SCHEMBL6890781 | 0.71 | LCK (0.69) | ALDH1A1LCKMAP2K3MAP2K6BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |