Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807646 | 0.82 | FAAH (0.38) | FAAH | |
| SCHEMBL18360599 | 0.78 | FAAH (0.39) | FAAHMCHR1 | |
| SCHEMBL18360640 | 0.78 | FAAH (0.40) | FAAHMCHR1CCR8 | |
| SCHEMBL15065565 | 0.78 | PIP5K1C (0.45) | — | |
| SCHEMBL15084329 | 0.66 | FAAH (0.51) | FAAHMCHR1HCRTR1HCRTR2 | |
| SCHEMBL15065068 | 0.64 | PIP5K1C (0.44) | — | |
| SCHEMBL18360666 | 0.63 | ROCK2 (0.44) | — | |
| SCHEMBL15065414 | 0.62 | — | — | |
| SCHEMBL15065500 | 0.62 | — | — | |
| SCHEMBL12073932 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |