Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1548221 | 0.71 | HSD11B1 (0.41) | HSD11B1CYP2C9EPHX2L3MBTL1ALDH1A1 | |
| SCHEMBL27742860 | 0.71 | L3MBTL1 (0.42) | HSD11B1CYP2C9EPHX2L3MBTL1MEN1 | |
| SCHEMBL354360 | 0.71 | HSD11B1 (0.41) | HSD11B1CYP2C9EPHX2L3MBTL1HSD17B10 | |
| SCHEMBL26229896 | 0.70 | HSD11B1 (0.40) | HSD11B1CYP2C9EPHX2L3MBTL1HSD17B10 | |
| Bicarbonate SCHEMBL20943643 | 0.69 | HSD11B1 (0.43) | HSD11B1CYP2C9EPHX2L3MBTL1MEN1 | |
| SCHEMBL4400851 | 0.68 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL7401344 | 0.67 | HSD11B1 (0.45) | HSD11B1CYP2C9EPHX2L3MBTL1KMT2A | |
| SCHEMBL11297336 | 0.67 | EPHX2 (0.34) | HSD11B1EPHX2ALDH1A1 | |
| SCHEMBL28913743 | 0.67 | HSD11B1 (0.38) | HSD11B1CYP2C9EPHX2L3MBTL1KMT2A | |
| SCHEMBL5401965 | 0.66 | HSD11B1 (0.48) | HSD11B1CYP2C9EPHX2L3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640072-B1 | Derivatives of pyridine as hydroxylase and lyase inhibitors | BTG INT LTD (GB) | 2000-08-23 | — | — | EP | disclosed |
| US-5595995-A | ANTICARCINOGENIC AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-01-21 | — | — | US | disclosed |
| EP-0640072-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BTG INTERNATIONAL LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023375-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |