Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPM1B | O75688 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076662 | 1.00 | LMNA (0.37) | LMNAPOLBPPM1BPTPN1PPP1CC | |
| SCHEMBL900783 | 0.77 | LMNA (0.43) | LMNAPOLBPPM1BPTPN1PPP1CC | |
| SCHEMBL17577372 | 0.72 | TSHR (0.46) | LMNAPPM1BPTPN1PPP1CCTSHR | |
| SCHEMBL18166910 | 0.72 | TSHR (0.46) | LMNAPPM1BPTPN1PPP1CCTSHR | |
| SCHEMBL2139493 | 0.68 | LMNA (0.40) | LMNAPOLBPPM1BPTPN1PPP1CC | |
| SCHEMBL21076384 | 0.67 | PPM1B (0.36) | PPM1BPTPN1PPP1CCKDM4ETSHR | |
| SCHEMBL14966710 | 0.66 | SOAT1 (0.39) | LMNAPOLBPPM1BPTPN1PPP1CC | |
| SCHEMBL14967349 | 0.66 | PPM1B (0.42) | LMNAPOLBPPM1BPTPN1PPP1CC | |
| SCHEMBL18166928 | 0.64 | ALDH1A1 (0.37) | LMNAPPM1BPTPN1PPP1CCKDM4E | |
| SCHEMBL4157000 | 0.63 | LMNA (0.60) | LMNAPPM1BPTPN1PPP1CCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821668-B1 | DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR | BRITISH BIOTECH PHARM (GB) | 2000-08-23 | — | — | EP | disclosed |
| US-5908851-A | TUMOR NECROSIS FACTOR, COLLAGENASE, STROMELYSIN, AND GELATINASE INHIBITORS; OSTEOPOROSIS, RHEUMATIC AND ORAL DISEASES; ANTIARTHRITIC AND ANTIULCER AGENTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-06-01 | — | — | US | disclosed |
| EP-0821668-A1 | DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033165-A1 | DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-10-24 | — | — | WO | disclosed |