Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.58 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807926 | 0.91 | ITK (0.59) | ITKRORCDHODHSSTR5TBK1 | |
| SCHEMBL807946 | 0.88 | ITK (0.58) | ITKRORCDHODHSSTR5LCK | |
| SCHEMBL808093 | 0.87 | ITK (0.61) | ITKRORCDHODHSSTR5LCK | |
| SCHEMBL807743 | 0.87 | ITK (0.57) | ITKRORCDHODHSSTR5LCK | |
| SCHEMBL807541 | 0.87 | ITK (0.55) | ITKRORCDHODHSSTR5TBK1 | |
| SCHEMBL10285825 | 0.85 | ITK (0.58) | ITKRORCDHODHSSTR5LCK | |
| SCHEMBL807716 | 0.84 | ITK (0.60) | ITKRORCDHODHLCKAURKB | |
| SCHEMBL807822 | 0.84 | ITK (0.81) | ITKRORCDHODHSSTR5LCK | |
| SCHEMBL808081 | 0.83 | ITK (0.54) | ITKRORCDHODHSSTR5TBK1 | |
| SCHEMBL2395616 | 0.82 | ITK (0.56) | ITKRORCDHODHSSTR5LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |