Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.60 |
| ▸ | BTK | Q06187 | 6/20 | 0.42 |
| ▸ | HCK | P08631 | 5/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793964 | 0.95 | ITK (0.56) | ITKBTKHCKLCKAURKB | |
| SCHEMBL807822 | 0.85 | ITK (0.81) | ITKBTKHCKADORA3ADORA2A | |
| SCHEMBL807926 | 0.85 | ITK (0.59) | ITKBTKHCKADORA3ADORA2A | |
| SCHEMBL807803 | 0.84 | ITK (0.58) | ITKBTKHCKADORA3ADORA2A | |
| SCHEMBL793965 | 0.82 | ITK (0.56) | ITKBTKHCKLCKAURKB | |
| SCHEMBL807541 | 0.80 | ITK (0.55) | ITKLCKAURKBCCNA2CDK2 | |
| SCHEMBL2371318 | 0.78 | ITK (0.62) | ITKBTKLCKAURKB | |
| SCHEMBL2371312 | 0.78 | ITK (0.62) | ITKBTKLCKAURKB | |
| SCHEMBL20767484 | 0.75 | ITK (1.00) | ITKBTKHCKLCKAURKB | |
| SCHEMBL20767486 | 0.75 | ITK (1.00) | ITKBTKHCKLCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |