Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LAP3 | P28838 | 3/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082386 | 0.80 | NOS2 (0.32) | — | |
| SCHEMBL8082365 | 0.79 | HPGD (0.41) | CSNK1EALDH1A1LAP3RENANPEP | |
| SCHEMBL8187966 | 0.78 | CSNK1E (0.36) | CSNK1EALDH1A1LAP3RENANPEP | |
| Hydrochloric Acid SCHEMBL8080750 | 0.74 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL8080759 | 0.74 | CA12 (0.37) | CSNK1E | |
| SCHEMBL6272634 | 0.72 | NOS2 (0.50) | LMNA | |
| SCHEMBL6272635 | 0.72 | NOS2 (0.50) | LMNA | |
| SCHEMBL8077802 | 0.72 | MTNR1A (0.41) | — | |
| SCHEMBL10722746 | 0.72 | METAP2 (0.46) | METAP2LAP3ANPEPRNPEPDNPEP | |
| Hydrochloric Acid SCHEMBL8067658 | 0.71 | NOS2 (0.49) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143790-A | ENZYME INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0749418-B1 | L-N6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1995024382-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-09-14 | — | — | WO | disclosed |