Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8433192 | 0.82 | KMT2A (0.57) | KMT2AMEN1POLBTDP1MAPT | |
| SCHEMBL8084666 | 0.82 | MAPT (0.60) | KMT2AMEN1POLBMAPTNPC1 | |
| SCHEMBL18177840 | 0.78 | ALDH1A1 (0.76) | KMT2AMEN1POLBMAPTNPC1 | |
| SCHEMBL8290704 | 0.76 | ALDH1A1 (0.61) | KMT2AMEN1POLBTDP1MAPT | |
| SCHEMBL11222973 | 0.74 | MAPT (0.61) | KMT2AMEN1POLBMAPTNPC1 | |
| SCHEMBL16468198 | 0.73 | ALDH1A1 (0.43) | KMT2AMEN1POLBTDP1NPC1 | |
| SCHEMBL15300921 | 0.73 | ALDH1A1 (0.67) | KMT2AMEN1POLBTDP1MAPT | |
| SCHEMBL1713424 | 0.73 | ALDH1A1 (0.63) | KMT2AMEN1POLBTDP1MAPT | |
| SCHEMBL7032108 | 0.72 | MAPT (0.54) | KMT2AMEN1POLBTDP1MAPT | |
| SCHEMBL26293248 | 0.72 | ALPL (0.45) | KMT2AMEN1MAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |