Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079894 | 0.82 | KMT2A (0.57) | MAPTNPC1LMNACASP3SENP8 | |
| SCHEMBL4511288 | 0.71 | HTT (0.57) | NPC1SMN1; SMN2RAB9AKMT2APKM | |
| SCHEMBL6539261 | 0.71 | PLA2G4B (0.60) | MAPTSRD5A2ALDH1A1KMT2APKM | |
| SCHEMBL8086185 | 0.71 | PKM (0.79) | MAPTRAB9AALDH1A1PKMPLA2G4B | |
| SCHEMBL7315727 | 0.71 | PKM (0.79) | ALDH1A1PKMPLA2G4BNR4A1NR4A2 | |
| SCHEMBL2835976 | 0.71 | ALDH1A1 (0.61) | MAPTLMNASRD5A2ALDH1A1KMT2A | |
| SCHEMBL11222973 | 0.71 | MAPT (0.61) | MAPTNPC1LMNACASP3SENP8 | |
| SCHEMBL8569877 | 0.70 | PKM (0.78) | SRD5A2ALDH1A1PKMPLA2G4BNR4A1 | |
| SCHEMBL7610156 | 0.70 | PKM (0.77) | PKMPLA2G4BRARB | |
| SCHEMBL4949143 | 0.70 | NR4A2 (0.90) | NPC1SRD5A2SMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | claimed |