Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070724 | 0.89 | SRD5A2 (1.00) | SRD5A2MAPTNPC1LMNACASP3 | |
| SCHEMBL8079934 | 0.78 | SRD5A2 (0.78) | SRD5A2MAPTLMNASMN1; SMN2PTGES | |
| SCHEMBL6225616 | 0.71 | ALDH1A1 (0.46) | SRD5A2MAPTLMNASMN1; SMN2POLB | |
| SCHEMBL8084666 | 0.68 | MAPT (0.60) | SRD5A2MAPTNPC1LMNACASP3 | |
| SCHEMBL8437380 | 0.67 | SRD5A2 (0.65) | SRD5A2LMNAPTGESCRHBPCRHR2 | |
| SCHEMBL8079894 | 0.66 | KMT2A (0.57) | MAPTNPC1LMNACASP3SENP8 | |
| SCHEMBL8079931 | 0.65 | SRD5A2 (1.00) | SRD5A2MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL6961165 | 0.63 | CYP2C9 (0.67) | MAPTRAPGEF3SMN1; SMN2MAPK1CYP2C9 | |
| SCHEMBL27421511 | 0.62 | KMT2A (0.59) | MAPTNPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL6225496 | 0.61 | CRHBP (0.54) | SMN1; SMN2MAPK1POLBHTTCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | claimed |