Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795542 | 0.87 | SCN9A (0.41) | SCN9ANPSR1MGAT2GABRA5HDAC6 | |
| SCHEMBL795751 | 0.84 | L3MBTL1 (0.45) | NPSR1MGAT2GABRA5HDAC6HDAC4 | |
| SCHEMBL796094 | 0.80 | SCN9A (0.36) | SCN9ANPSR1GABRA5HDAC6HDAC4 | |
| SCHEMBL794771 | 0.79 | HDAC4 (0.40) | HDAC6HDAC4HDAC1S1PR1 | |
| SCHEMBL15476937 | 0.79 | GABRA5 (0.36) | SCN9ANPSR1GABRA5HDAC6HDAC1 | |
| SCHEMBL796232 | 0.79 | SCN9A (0.37) | SCN9ANPSR1GABRA5HDAC6ALDH1A1 | |
| SCHEMBL796334 | 0.79 | SCN9A (0.39) | SCN9ANPSR1HDAC6ALDH1A1RECQL | |
| SCHEMBL795996 | 0.78 | SCN9A (0.38) | SCN9ANPSR1MGAT2GABRA5HDAC6 | |
| SCHEMBL796075 | 0.77 | ALDH1A1 (0.38) | SCN9ANPSR1GABRA5HDAC6HDAC4 | |
| SCHEMBL10287779 | 0.77 | NPSR1 (0.40) | SCN9ANPSR1MGAT2GABRA5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-B1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2015-11-04 | — | — | EP | disclosed |
| US-20150025057-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2015-01-22 | — | — | US | disclosed |
| US-8895733-B2 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-20140051676-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-02-20 | — | — | US | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025057-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | SCN9A 1051/4885NPSR1 101/4885MGAT2 1882/4885 |
| US-20140051676-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | SCN9A 1051/4885NPSR1 101/4885MGAT2 1882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.