Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.46 |
| ▸ | ITK | Q08881 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12470060 | 0.93 | LCK (0.47) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL10286441 | 0.86 | ITK (0.47) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL807802 | 0.85 | NPC1 (0.47) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL793708 | 0.80 | LCK (0.40) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL799038 | 0.76 | POLB (0.44) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL807713 | 0.76 | ITK (0.41) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL10285615 | 0.70 | LCK (0.40) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL179069 | 0.70 | ITK (0.61) | LCKITKAURKBSRC | |
| SCHEMBL807804 | 0.70 | LCK (0.46) | LCKITKAURKBPOLBNPC1 | |
| SCHEMBL807917 | 0.68 | LCK (0.39) | LCKITKAURKBPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |