Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081514 | 0.88 | TARBP2 (0.43) | TARBP2KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8085093 | 0.88 | KDM4E (0.43) | TARBP2KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8468564 | 0.86 | TARBP2 (0.39) | TARBP2KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8072434 | 0.85 | TARBP2 (0.38) | TARBP2FAAHKDM4EKMT2AMEN1 | |
| SCHEMBL8072500 | 0.79 | XDH (0.37) | KMT2AMEN1ALDH1A1HPGDTP53 | |
| SCHEMBL8082276 | 0.74 | FABP4 (0.38) | FAAHKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8086618 | 0.74 | ALOX5 (0.52) | FAAHKMT2AMEN1ALDH1A1PDE1A | |
| SCHEMBL8080755 | 0.73 | TARBP2 (0.42) | TARBP2KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL7663000 | 0.73 | KMT2A (0.43) | TARBP2KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8072645 | 0.73 | PDE1A (0.44) | TARBP2KDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |