Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081635 | 0.86 | ALOX5 (0.40) | TDP1MEN1KMT2AALOX5NPC1 | |
| SCHEMBL8081513 | 0.85 | ALOX5 (0.46) | TDP1KDM4EALDH1A1RECQLMAPT | |
| SCHEMBL8082083 | 0.83 | TDP1 (0.42) | TDP1KDM4EALDH1A1RECQLMAPT | |
| SCHEMBL8082065 | 0.81 | ALOX5 (0.45) | MEN1KMT2AALOX5NPC1RAB9A | |
| SCHEMBL8085195 | 0.78 | MAPT (0.45) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8085152 | 0.76 | ALOX5 (0.38) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8082048 | 0.74 | MEN1 (0.39) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL8072357 | 0.72 | ALOX5 (0.44) | TDP1KDM4EALDH1A1RECQLMAPT | |
| SCHEMBL8080604 | 0.71 | ALOX5 (0.50) | TDP1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL2959109 | 0.71 | ALOX5 (0.48) | MEN1KMT2AALOX5PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |