Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086666 | 0.87 | PTGS2 (0.44) | NQO2MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL8072409 | 0.85 | NPC1 (0.38) | NQO2CYP19A1MEN1RAB9AKMT2A | |
| SCHEMBL8081635 | 0.85 | ALOX5 (0.40) | ALOX5NQO2BRD4PDE10AMEN1 | |
| SCHEMBL8085195 | 0.85 | MAPT (0.45) | ALOX5NQO2MAPK1CYP19A1MEN1 | |
| SCHEMBL8082332 | 0.84 | MAP2K4 (0.37) | NQO2MAP2K4CYP19A1MEN1KMT2A | |
| SCHEMBL8084922 | 0.83 | ALOX5 (0.53) | ALOX5NQO2BRD4MAPK1MAP2K4 | |
| SCHEMBL8085152 | 0.82 | ALOX5 (0.38) | ALOX5NQO2PDE10AMEN1RAB9A | |
| SCHEMBL8080877 | 0.81 | ALOX5 (0.43) | ALOX5NQO2BRD4MAPK1MAP2K4 | |
| SCHEMBL8082003 | 0.81 | TDP1 (0.44) | ALOX5NQO2BRD4PDE10AMEN1 | |
| SCHEMBL8082083 | 0.78 | TDP1 (0.42) | ALOX5BRD4MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |