Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082048 | 0.87 | MEN1 (0.39) | EDNRAPARP1EDNRBALOX5ALDH1A1 | |
| SCHEMBL8072357 | 0.86 | ALOX5 (0.44) | TDP1EDNRAPARP1EDNRBTOP1 | |
| SCHEMBL8085195 | 0.84 | MAPT (0.45) | EDNRAEDNRBRAB9AALOX5ALDH1A1 | |
| SCHEMBL8082003 | 0.83 | TDP1 (0.44) | TDP1TOP1RAB9AALOX5ALDH1A1 | |
| SCHEMBL8085152 | 0.81 | ALOX5 (0.38) | EDNRAEDNRBRAB9AALOX5ALDH1A1 | |
| SCHEMBL8086569 | 0.81 | RAB9A (0.44) | TDP1EDNRAEDNRBRAB9ASLC6A9 | |
| SCHEMBL8082065 | 0.78 | ALOX5 (0.45) | RAB9AALOX5MEN1KMT2ABRD4 | |
| SCHEMBL8081635 | 0.78 | ALOX5 (0.40) | TDP1EDNRARAB9AALOX5MEN1 | |
| SCHEMBL8085138 | 0.76 | ALOX5 (0.46) | EDNRAPARP1EDNRBRAB9AALOX5 | |
| SCHEMBL8080564 | 0.74 | CDK2 (0.41) | EDNRAEDNRBRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |