Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082003 | 0.86 | TDP1 (0.44) | ALOX5BRD4NQO2PDE10ATDP1 | |
| SCHEMBL8082065 | 0.85 | ALOX5 (0.45) | ALOX5BRD4NQO2PDE10AMEN1 | |
| SCHEMBL8080604 | 0.84 | ALOX5 (0.50) | ALOX5BRD4NQO2PDE10ATDP1 | |
| SCHEMBL8085195 | 0.82 | MAPT (0.45) | ALOX5NQO2MEN1KMT2ANPC1 | |
| Dimethylamine SCHEMBL8081518 | 0.81 | ALOX5 (0.47) | ALOX5BRD4NQO2PDE10ATDP1 | |
| SCHEMBL8082048 | 0.80 | MEN1 (0.39) | ALOX5MEN1KMT2AEDNRA | |
| SCHEMBL8085152 | 0.80 | ALOX5 (0.38) | ALOX5NQO2PDE10AMEN1KMT2A | |
| SCHEMBL8082083 | 0.78 | TDP1 (0.42) | ALOX5BRD4TDP1MEN1KMT2A | |
| SCHEMBL2959109 | 0.74 | ALOX5 (0.48) | ALOX5PDE10AMEN1KMT2A | |
| SCHEMBL8086666 | 0.73 | PTGS2 (0.44) | NQO2HSP90AA1HSP90AB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |