Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | LAP3 | P28838 | 2/20 | 0.43 |
| ▸ | KLK8 | O60259 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KLK2 | P20151 | 1/20 | 0.42 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836998 | 0.88 | SRC (0.57) | SRCHTTANPEPLAP3KLK8 | |
| SCHEMBL916423 | 0.80 | SRC (0.48) | SRCHTTLMNAANPEPLAP3 | |
| SCHEMBL27882402 | 0.79 | LMNA (0.52) | SRCHTTLMNAANPEPLAP3 | |
| SCHEMBL8046728 | 0.77 | CXCL8 (0.46) | CYP19A1HTTSMN1; SMN2ALPLALPI | |
| SCHEMBL27882400 | 0.77 | MAOA (0.47) | SRCSMN1; SMN2ANPEPLAP3KLK8 | |
| SCHEMBL22321983 | 0.77 | SRC (0.44) | SRCHTTLMNAANPEPLAP3 | |
| SCHEMBL22321985 | 0.77 | ALDH1A1 (0.50) | SRCHTTSMN1; SMN2PLAU | |
| SCHEMBL13538164 | 0.75 | CA1 (0.55) | SRCHTTSMN1; SMN2LMNACYP3A4 | |
| SCHEMBL16238910 | 0.74 | ALDH1A1 (0.49) | SRCHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL27882575 | 0.73 | PARP10 (0.56) | CYP3A4ANPEPLAP3KLK8PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044206-A1 | PRODRUGS OF NAALADASE INHIBITORS | Guildford Pharmaceuticals Inc. (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999033849-A1 | PRODRUGS OF NAALADASE INHIBITORS | GUILDFORD PHARMACEUTICALS INC. (US) | 1999-07-08 | — | — | WO | disclosed |