Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083616 | 0.90 | ATR (0.42) | ATRPIK3CDPIK3CAMTORALDH1A1 | |
| SCHEMBL8097448 | 0.86 | PIK3CA (0.43) | ATRPIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8083011 | 0.86 | ATR (0.39) | ATRPIK3CDPIK3CAMTORALDH1A1 | |
| SCHEMBL8103635 | 0.86 | ATR (0.39) | ATRPIK3CDPIK3CAMTORALDH1A1 | |
| SCHEMBL8084155 | 0.85 | MAPT (0.39) | ATRPIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL8091635 | 0.85 | ATR (0.47) | ATRPIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8096243 | 0.85 | PIK3CD (0.46) | ATRPIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL8096240 | 0.84 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8097689 | 0.83 | ALDH1A1 (0.40) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8092197 | 0.83 | PIK3CD (0.49) | ATRPIK3CDPIK3CAPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |