Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089531 | 0.89 | CA12 (0.43) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL8083616 | 0.88 | ATR (0.42) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8099845 | 0.86 | KDR (0.41) | PIK3CDPIK3CA | |
| SCHEMBL8091998 | 0.85 | KIF11 (0.40) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8083011 | 0.84 | ATR (0.39) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8103635 | 0.84 | ATR (0.39) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8090994 | 0.84 | POLB (0.39) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL8091293 | 0.82 | MAPT (0.42) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8090868 | 0.81 | MTOR (0.38) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8099604 | 0.81 | PIK3CD (0.36) | KIF11MEN1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |