Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.38 |
| ▸ | MTOR | P42345 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084284 | 0.90 | NAMPT (0.39) | NAMPTPIK3CDPIK3CAMAPTALDH1A1 | |
| SCHEMBL8099632 | 0.86 | CA1 (0.42) | NAMPTPIK3CDPIK3CAMTORALDH1A1 | |
| SCHEMBL8090837 | 0.84 | MTOR (0.38) | NAMPTPIK3CDPIK3CAMTORMAPT | |
| SCHEMBL8091717 | 0.84 | CA2 (0.40) | NAMPTPIK3CDPIK3CAMTORMAPT | |
| SCHEMBL8091538 | 0.84 | PIK3CD (0.43) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8089194 | 0.83 | MTOR (0.38) | NAMPTPIK3CDMTORMAPTALDH1A1 | |
| SCHEMBL8099563 | 0.83 | PIK3CA (0.38) | PIK3CDPIK3CAMTORALDH1A1POLB | |
| SCHEMBL8084009 | 0.83 | PIK3CD (0.42) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8104327 | 0.83 | NAMPT (0.39) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL4212278 | 0.83 | MTOR (0.55) | PIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |