Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.33 |
| ▸ | FLT1 | P17948 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203967 | 0.84 | MTOR (0.53) | MTORPIK3R1PIK3CD | |
| SCHEMBL8091534 | 0.83 | NAMPT (0.40) | MTORNAMPTPOLBTP53MAPT | |
| SCHEMBL8084284 | 0.83 | NAMPT (0.39) | NAMPTPOLBTP53MAPTHPGD | |
| SCHEMBL8091693 | 0.81 | MTOR (0.40) | MTORKDRNTRK1RETEPHB2 | |
| SCHEMBL8096057 | 0.80 | MTOR (0.43) | MTORPIK3CD | |
| SCHEMBL8083835 | 0.79 | MTOR (0.39) | MTORKDRNTRK1RETEPHB2 | |
| SCHEMBL8089909 | 0.78 | MTOR (0.45) | MTORDYRK1APIK3CD | |
| SCHEMBL8099962 | 0.75 | ALDH1A1 (0.45) | MAPTHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8097088 | 0.74 | TSHR (0.47) | NAMPTAURKBALDH1A1TSHRPIK3CD | |
| SCHEMBL4207735 | 0.73 | MTOR (0.46) | MTORKDRPIK3R1FGFR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |