Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085417 | 0.88 | MALT1 (0.37) | MALT1PGRMEN1KMT2AMAPT | |
| SCHEMBL8088791 | 0.86 | ABCC9 (0.39) | ABCC9MALT1VCAM1P2RY6ABCB1 | |
| SCHEMBL8085230 | 0.85 | ABCC9 (0.39) | ABCC9MALT1VCAM1P2RY6 | |
| SCHEMBL8088508 | 0.85 | ABCC9 (0.39) | ABCC9MALT1VCAM1P2RY6ABCB1 | |
| SCHEMBL7267033 | 0.84 | MALT1 (0.35) | ABCC9MALT1ABCB1 | |
| SCHEMBL8077233 | 0.84 | ABCC9 (0.40) | ABCC9MALT1ABCB1 | |
| SCHEMBL8085328 | 0.84 | ABCC9 (0.36) | ABCC9MALT1ABCB1MAPT | |
| SCHEMBL8090111 | 0.82 | RARA (0.36) | ABCC9MALT1ABCB1MAPT | |
| SCHEMBL8084273 | 0.81 | VCAM1 (0.38) | ABCC9MALT1VCAM1P2RY6MAPT | |
| SCHEMBL8077169 | 0.81 | ABCC9 (0.36) | ABCC9MALT1VCAM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |