SCHEMBL8097197

SCHEMBL8097197

O=C(CCCCc1cccc(Cl)c1)N1CCC(c2ccccc2)CC1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 2/20 0.55
ADAMTS5 Q9UNA0 1/20 0.51
ALDH1A1 P00352 3/20 0.48
POLB P06746 1/20 0.48
TSHR P16473 2/20 0.47
KDM4E B2RXH2 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
SIGMAR1 Q99720 2/20 0.47
TP53 P04637 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C19 P33261 1/20 0.47
CCR1 P32246 1/20 0.47
CACNA1G O43497 1/20 0.47
CACNA1H O95180 1/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8092824 0.88 SIGMAR1 (0.59) ADAMTS5ALDH1A1POLBTSHRSMN1; SMN2
SCHEMBL8091568 0.87 MEN1 (0.54) ALDH1A1TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL8091251 0.84 SIGMAR1 (0.54) ALDH1A1SIGMAR1LMNA
SCHEMBL3878560 0.83 CCR1 (0.58) POLBMEN1KMT2ACCR1CACNA1G
SCHEMBL8084480 0.82 NAAA (0.62) NAAAALDH1A1MEN1KMT2AHPGD
SCHEMBL8092580 0.81 GRM5 (0.53) NAAAALDH1A1MEN1KMT2ACCR1
SCHEMBL9377300 0.80 DRD2 (0.53) NAAAADAMTS5ALDH1A1POLBTSHR
SCHEMBL8084591 0.80 MCHR1 (0.48) NAAAALDH1A1MEN1KMT2ACCR1
SCHEMBL8092966 0.77 ALDH1A1 (0.64) ALDH1A1TSHRKDM4EKMT2ASIGMAR1
SCHEMBL30616896 0.77 ADAMTS5 (0.47) NAAAADAMTS5ALDH1A1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed