Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30279827 | 0.92 | HSD17B1 (0.49) | XDHSNCAHSD17B1HSD17B2CYP3A4 | |
| SCHEMBL13191551 | 0.87 | HSD17B1 (0.46) | XDHTRPV1SNCAHSD17B1HSD17B2 | |
| SCHEMBL18167775 | 0.87 | KIF11 (0.45) | XDHSNCAHSD17B1HSD17B2CYP3A4 | |
| SCHEMBL7218452 | 0.80 | CSNK2A1 (0.55) | HDAC6HDAC1HDAC4 | |
| SCHEMBL8085528 | 0.80 | GCK (0.45) | XDHHSD17B1HSD17B2CYP3A4CYP2C9 | |
| SCHEMBL13494529 | 0.79 | MAPT (0.44) | HSD17B1HSD17B2CYP3A4CYP2C9KIF11 | |
| SCHEMBL10630306 | 0.77 | GCK (0.39) | HSD17B1HSD17B2CYP3A4CYP2C9KIF11 | |
| SCHEMBL21484979 | 0.77 | KIF11 (0.41) | SNCAHSD17B1HSD17B2CYP3A4CYP2C9 | |
| SCHEMBL10464166 | 0.77 | TP53 (0.42) | HSD17B1HSD17B2CYP3A4CYP2C9KIF11 | |
| SCHEMBL3057473 | 0.75 | KIF11 (0.44) | TRPV1HDAC6HDAC1KIF11CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011048-A | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity | MERCK & CO., INC. (US) | 2000-01-04 | — | — | US | disclosed |