Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.45 |
| ▸ | GCKR | Q14397 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193542 | 0.87 | HSD17B1 (0.48) | MMP2MMP9CYP3A4CYP2C9HSD17B1 | |
| SCHEMBL30279827 | 0.87 | HSD17B1 (0.49) | KIF11XDHCYP3A4CYP2C9HSD17B1 | |
| SCHEMBL18167775 | 0.82 | KIF11 (0.45) | GCKGCKRKIF11XDHCYP3A4 | |
| SCHEMBL13191551 | 0.82 | HSD17B1 (0.46) | KIF11XDHCYP3A4CYP2C9HSD17B1 | |
| SCHEMBL8084594 | 0.80 | XDH (0.57) | KIF11XDHCYP3A4CYP2C9HSD17B1 | |
| SCHEMBL3071920 | 0.78 | KIF11 (0.66) | KIF11MMP2MMP9KDM1APTGS2 | |
| SCHEMBL7218452 | 0.78 | CSNK2A1 (0.55) | HDAC6HDAC1KDM4EALDH1A1HDAC4 | |
| SCHEMBL61336 | 0.76 | KIF11 (0.55) | KIF11ALDH1A1MAPTPTGS2CA1 | |
| SCHEMBL13494529 | 0.75 | MAPT (0.44) | KIF11CYP3A4CYP2C9HSD17B1HSD17B2 | |
| SCHEMBL10464166 | 0.72 | TP53 (0.42) | KIF11CYP3A4CYP2C9HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011048-A | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity | MERCK & CO., INC. (US) | 2000-01-04 | — | — | US | disclosed |