Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 6/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274240 | 0.83 | ABCC9 (0.62) | ABCC9ABCB1 | |
| SCHEMBL8085013 | 0.82 | ABCC9 (0.41) | ABCC9NPC1RAB9A | |
| SCHEMBL8088486 | 0.81 | ABCC9 (0.42) | ABCC9NPC1RAB9A | |
| SCHEMBL9589063 | 0.81 | ABCC9 (0.48) | ABCC9KCNE1KCNQ1ABCB1 | |
| SCHEMBL9589058 | 0.81 | ABCC9 (0.48) | ABCC9KCNE1KCNQ1ABCB1 | |
| SCHEMBL9589053 | 0.81 | ABCC9 (0.48) | ABCC9KCNE1KCNQ1ABCB1 | |
| SCHEMBL7324168 | 0.79 | ABCC9 (0.38) | ABCC9KCNE1KCNQ1 | |
| SCHEMBL7330531 | 0.79 | ABCC9 (0.38) | ABCC9KCNE1KCNQ1 | |
| SCHEMBL8076897 | 0.78 | ABCC9 (0.38) | ABCC9KCNE1KCNQ1 | |
| SCHEMBL9565062 | 0.76 | TP53 (0.34) | AVPR1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |