Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072741 | 0.90 | ALOX5 (0.38) | ALOX5NPC1LMNAMAPTRAB9A | |
| SCHEMBL8082124 | 0.87 | PTGS2 (0.42) | ALOX5NPC1RAB9ASMN1; SMN2NQO2 | |
| SCHEMBL8084922 | 0.86 | ALOX5 (0.53) | ALOX5NPC1LMNAMAPTRAB9A | |
| SCHEMBL8082177 | 0.84 | ALOX5 (0.38) | ALOX5MAPTKDRNQO2CYP19A1 | |
| SCHEMBL8072409 | 0.84 | NPC1 (0.38) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8072861 | 0.80 | PTGS2 (0.42) | ALOX5NPC1LMNAMAPTRAB9A | |
| SCHEMBL8080610 | 0.79 | ALOX5 (0.50) | ALOX5NPC1LMNAMAPTRAB9A | |
| SCHEMBL8085115 | 0.79 | ALOX5 (0.53) | ALOX5NPC1LMNAMAPTRAB9A | |
| SCHEMBL8072516 | 0.77 | PTGS2 (0.40) | NPC1RAB9ASMN1; SMN2NQO2 | |
| SCHEMBL8085117 | 0.76 | ROCK2 (0.45) | ALOX5NPC1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |