Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080564 | 0.89 | CDK2 (0.41) | NPC1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL8086666 | 0.86 | PTGS2 (0.44) | NPC1SMN1; SMN2RAB9ANQO2CDK2 | |
| SCHEMBL8082065 | 0.85 | ALOX5 (0.45) | NPC1RAB9ANQO2CYP19A1MEN1 | |
| SCHEMBL8085294 | 0.84 | ALOX5 (0.38) | NPC1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL8082332 | 0.83 | MAP2K4 (0.37) | MAPTNQO2CDK2CYP19A1CYP1A2 | |
| SCHEMBL8086663 | 0.79 | PTGS2 (0.44) | NPC1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL8080517 | 0.79 | APP (0.41) | NPC1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL8085195 | 0.78 | MAPT (0.45) | NPC1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL8086669 | 0.76 | CYP19A1 (0.40) | NPC1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL8072741 | 0.75 | ALOX5 (0.38) | NPC1SMN1; SMN2LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |