Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088704 | 0.89 | ABCC9 (0.40) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8085433 | 0.88 | PDE4A (0.40) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8085331 | 0.88 | HSD17B10 (0.38) | MALT1 | |
| SCHEMBL8085358 | 0.87 | PDE4A (0.41) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8085300 | 0.85 | VCAM1 (0.39) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7266970 | 0.85 | ABCC9 (0.41) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8084413 | 0.85 | PDE4A (0.42) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8085153 | 0.82 | PDE4A (0.38) | ABCC9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8085230 | 0.82 | ABCC9 (0.39) | ABCC9VCAM1DCTPP1MALT1P2RY6 | |
| SCHEMBL9371559 | 0.82 | ABCC9 (0.39) | ABCC9VCAM1DCTPP1MALT1P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |