SCHEMBL8085682

SCHEMBL8085682

CN(C)c1ncc(C(=O)NCc2ccccc2)c(S)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.50
ADORA2A P29274 1/20 0.49
EGLN1 Q9GZT9 1/20 0.48
ALDH1A1 P00352 2/20 0.47
KMT2A Q03164 3/20 0.47
HPGD P15428 4/20 0.46
KDM4E B2RXH2 1/20 0.46
TACR3 P29371 1/20 0.46
NR3C1 P04150 1/20 0.46
CNR2 P34972 1/20 0.46
GAA P10253 2/20 0.45
HPGDS O60760 2/20 0.45
TP53 P04637 1/20 0.45
GLA P06280 1/20 0.45
LMNA P02545 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C19 P33261 1/20 0.45
ESR1 P03372 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8085672 0.85 NR3C1 (0.51) THRBADORA2AEGLN1ALDH1A1KMT2A
SCHEMBL8084871 0.80 HPGDS (0.64) THRBEGLN1ALDH1A1KMT2AHPGD
SCHEMBL8091001 0.75 HPGD (0.67) THRBALDH1A1KMT2AHPGDKDM4E
SCHEMBL12929680 0.74 HPGDS (0.60) THRBADORA2AALDH1A1KMT2AKDM4E
SCHEMBL31680569 0.69 KMT2A (0.89) KMT2AHPGDGAATP53GLA
SCHEMBL11901003 0.69 KMT2A (0.89) KMT2AHPGDGAATP53GLA
SCHEMBL8776773 0.69 KMT2A (0.69) KMT2AHPGDGAATP53GLA
SCHEMBL4060965 0.69 KMT2A (0.53) THRBEGLN1ALDH1A1KMT2ANR3C1
SCHEMBL27903143 0.68 HDAC2 (0.73) KMT2AHPGDKDM4EGAATP53
SCHEMBL8085695 0.68 RAB9A (0.53) THRBEGLN1ALDH1A1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6133270-A Isothiazolones and pharmaceutical formulations WARNER-LAMBERT COMPANY (US) 2000-10-17 US disclosed
US-6001863-A USEFUL AS ANTIVIRAL, ANTIINFLAMMATORY AND ANTIATHEROSCLEROSIS AGENT; ADMINISTERING TO THE PATIENT IN NEED OF ZINC EJECTION FROM NUCLEOCAPSID PROTEIN WARNER-LAMBERT COMPANY (US) 1999-12-14 US disclosed
US-5889034-A ANTIINFLAMMATORY AGENT; ANTIATHEROSCLEROSIS AGENT; VIRICIDES WARNER-LAMBERT COMPANY (US) 1999-03-30 US disclosed
US-5733921-A ANTIRETROVIRAL AGENTS; ANTIINFLAMMATORY AGENTS; ANTIATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1998-03-31 US disclosed
EP-0828488-A1 ISOTHIAZOLONES WARNER-LAMBERT COMPANY (US) 1998-03-18 EP disclosed
US-5668162-A Isothiazolones lower plasma levels of lipoprotein(a) WARNER-LAMBERT COMPANY 1997-09-16 US disclosed
US-5620997-A VIRICIDES, ANTIINFLAMMATORY AGENTS, ANTIATHEROSCLEROTIC AGENT WARNER-LAMBERT COMPANY (US) 1997-04-15 US disclosed
WO-1996038144-A1 ISOTHIAZOLONES WARNER-LAMBERT COMPANY (US) 1996-12-05 WO disclosed