Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorotriphenylmethane SCHEMBL8711570 | 0.91 | CNR1 (0.36) | KIF11MEN1TTRKMT2AGRIN1 | |
| SCHEMBL8659893 | 0.81 | TRPA1 (0.37) | KIF11MEN1TTRKMT2AGRIN1 | |
| SCHEMBL10770500 | 0.79 | MEN1 (0.38) | KIF11MEN1TTRKMT2AGRIN1 | |
| SCHEMBL8660267 | 0.76 | THRB (0.34) | KIF11MEN1TTRKMT2AGRIN1 | |
| SCHEMBL3399635 | 0.76 | CPA3 (0.49) | KIF11CYP2C19CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL914102 | 0.75 | KDM4E (0.39) | KIF11TDP1KDM4ELMNAMAPK1 | |
| SCHEMBL11290864 | 0.75 | KDM4E (0.33) | KIF11MEN1TTRKMT2AGRIN1 | |
| SCHEMBL17396368 | 0.74 | CPA3 (0.39) | GRIN1GRIN2AGRIN2DGRIN2CGRIN2B | |
| SCHEMBL6655136 | 0.74 | TAAR1 (0.41) | KIF11KDM4ELMNAMAPK1KCNN4 | |
| SCHEMBL34051 | 0.73 | FOLH1 (0.43) | MEN1TTRKMT2ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133452-A | REACTION OF OPTIONALLY SUBSTITUTED INDOLE-3-ACETAMIDES WITH OPTIONALLY SUBSTITUTED METHYL INDOLE-3-GLYOXYL REAGENT TO PREPARE POTENT PKC INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| US-5990319-A | REACTING INDOLYL-3-ACETAMIDE WITH INDOLYL-3-GLYOXYL REAGENT | ELI LILLY AND COMPANY (US) | 1999-11-23 | — | — | US | disclosed |
| US-5948907-A | DEPROTONATION OF THE CORRESPONDING AMIDE COMPOUND WITH A STRONG BASE | ELI LILLY AND COMPANY (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0825190-A1 | Synthesis of bisindolymaleimides | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |