Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080564 | 0.90 | CDK2 (0.41) | CDK2NQO2CYP19A1TARBP2MEN1 | |
| SCHEMBL8085195 | 0.88 | MAPT (0.45) | CDK2NQO2CYP19A1MEN1KMT2A | |
| SCHEMBL8086666 | 0.85 | PTGS2 (0.44) | PTGS2CDK2NQO2CYP19A1PTGS1 | |
| SCHEMBL8072861 | 0.84 | PTGS2 (0.42) | PTGS2CDK2NQO2CYP19A1TARBP2 | |
| SCHEMBL8072409 | 0.79 | NPC1 (0.38) | CDK2NQO2CYP19A1MEN1KMT2A | |
| SCHEMBL8081344 | 0.78 | PTGS2 (0.42) | PTGS2CDK2TARBP2MEN1KMT2A | |
| SCHEMBL8085152 | 0.77 | ALOX5 (0.38) | CDK2NQO2MEN1KMT2AALDH1A1 | |
| SCHEMBL8086669 | 0.76 | CYP19A1 (0.40) | CDK2NQO2CYP19A1TARBP2ALDH1A1 | |
| SCHEMBL8072741 | 0.74 | ALOX5 (0.38) | CDK2NQO2CYP19A1TARBP2ALDH1A1 | |
| SCHEMBL8084885 | 0.74 | PTGS2 (0.44) | PTGS2CDK2MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |