Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080564 | 0.85 | CDK2 (0.41) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8072741 | 0.81 | ALOX5 (0.38) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8084890 | 0.79 | EDNRA (0.45) | ALDH1A1HPGDNPC1EDNRAEDNRB | |
| SCHEMBL8081346 | 0.78 | NPC1 (0.48) | MAPTSMN1; SMN2ALDH1A1CYP3A4HPGD | |
| SCHEMBL8072409 | 0.76 | NPC1 (0.38) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8086663 | 0.76 | PTGS2 (0.44) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8085195 | 0.74 | MAPT (0.45) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8081515 | 0.73 | EDNRA (0.45) | ALDH1A1CYP3A4HPGDNPC1RAB9A | |
| SCHEMBL8085294 | 0.72 | ALOX5 (0.38) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8072861 | 0.71 | PTGS2 (0.42) | CYP19A1NQO2LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |