Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 6/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084890 | 0.90 | EDNRA (0.45) | EDNRBTARBP2CDK2EDNRAALDH1A1 | |
| SCHEMBL8084976 | 0.88 | EDNRB (0.50) | EDNRBEDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL8081363 | 0.85 | PTGS2 (0.44) | PTGS2EDNRBEDNRAALDH1A1KDM4E | |
| SCHEMBL8072887 | 0.85 | PTGS2 (0.43) | PTGS2EDNRBEDNRAALDH1A1KDM4E | |
| SCHEMBL8081515 | 0.80 | EDNRA (0.45) | EDNRBEDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL8081346 | 0.78 | NPC1 (0.48) | TARBP2EDNRAALDH1A1KDM4EHPGD | |
| SCHEMBL8086663 | 0.78 | PTGS2 (0.44) | PTGS2TARBP2CDK2ALDH1A1KDM4E | |
| SCHEMBL8080596 | 0.78 | PTGS2 (0.42) | PTGS2TARBP2ALDH1A1KDM4EHPGD | |
| SCHEMBL8072861 | 0.76 | PTGS2 (0.42) | PTGS2TARBP2CDK2ALDH1A1KDM4E | |
| SCHEMBL8467959 | 0.74 | PTGS2 (0.42) | PTGS2EDNRBALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |