Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085115 | 0.81 | ALOX5 (0.53) | ALOX5KDM4EALDH1A1RAB9APLK4 | |
| SCHEMBL8080333 | 0.81 | ALOX5 (0.47) | ALOX5ALDH1A1RAB9AEDNRBEDNRA | |
| SCHEMBL8072504 | 0.78 | ALOX5 (0.56) | ALOX5KDM4EALDH1A1ROCK2CDK2 | |
| SCHEMBL8084967 | 0.78 | ALOX5 (0.56) | ALOX5KDM4EALDH1A1RAB9ACDK2 | |
| SCHEMBL8081502 | 0.78 | ALOX5 (0.55) | ALOX5KDM4ERAB9ACDK2CLK4 | |
| SCHEMBL8080562 | 0.76 | ALOX5 (0.56) | ALOX5KDM4EPIM1CDK2CSNK1A1 | |
| SCHEMBL8084927 | 0.76 | ALOX5 (0.56) | ALOX5CDK2 | |
| SCHEMBL2952410 | 0.76 | ALOX5 (0.71) | ALOX5KDM4EALDH1A1RAB9AMAPKAPK2 | |
| SCHEMBL8072251 | 0.76 | ALOX5 (0.53) | ALOX5ALDH1A1CDK2MAPKAPK2SMN1; SMN2 | |
| SCHEMBL8072655 | 0.75 | ALOX5 (0.54) | ALOX5KDM4EPIM1CDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |