SCHEMBL8087285

SCHEMBL8087285

[c]1cc(-c2cccnc2)nc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.47
DHODH Q02127 1/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
CYP2A6 P11509 4/20 0.46
F2 P00734 1/20 0.46
HPGD P15428 1/20 0.46
CYP2C9 P11712 4/20 0.45
ALDH1A1 P00352 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
MAPK1 P28482 1/20 0.43
KDM4E B2RXH2 1/20 0.43
LDHA P00338 1/20 0.43
EPHX2 P34913 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CYP11B1 P15538 1/20 0.41
AXL P30530 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL234452 0.83 ACHE (0.47) DHODHRAB9AHPGDALDH1A1KDM4E
SCHEMBL8087264 0.81 CYP2C9 (0.53) DHODHNPC1RAB9AHPGDCYP2C9
SCHEMBL4875167 0.78 MAPT (0.46) NPC1RAB9AHPGDALDH1A1KDM4E
SCHEMBL8094325 0.77 METAP2 (0.45) NPC1RAB9ACYP2A6CYP3A4KDM4E
SCHEMBL4912670 0.73 ALDH1A1 (0.45) NPC1RAB9AHPGDALDH1A1CYP1A2
SCHEMBL4901955 0.73 CYP1A1 (0.41) NPC1RAB9AALDH1A1CYP1A2MAPK1
SCHEMBL4907021 0.73 NPC1 (0.53) NPC1RAB9ACYP1A2KDM4EMEN1
SCHEMBL5780643 0.73 CYP19A1 (0.47) CYP19A1DHODHNPC1RAB9AHPGD
SCHEMBL5756985 0.73 ACP1 (0.43) NPC1RAB9AALDH1A1KDM4EMEN1
SCHEMBL547311 0.73 PDGFRB (0.49) CYP2A6HPGDALDH1A1CYP1A2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6063956-A APPLYING FUNGICIDE OR INSECTICIDE TO THE LOCUS WHERE CONTROL IS DESIRED ROHM AND HAAS COMPANY (US) 2000-05-16 US disclosed