SCHEMBL808824

SCHEMBL808824

COC(=O)C1C(/C=C(\C)Cl)C1(C)C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.49
TSHR P16473 4/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
TDP1 Q9NUW8 4/20 0.37
KMT2A Q03164 4/20 0.37
MEN1 O00255 3/20 0.37
ATM Q13315 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
ADRA2A P08913 1/20 0.36
CNR1 P21554 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALDH1A1 P00352 2/20 0.35
MAPT P10636 2/20 0.35
HTT P42858 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL808825 1.00 LMNA (0.49) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL10938588 0.89 LMNA (0.47) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL293469 0.89 LMNA (0.47) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL4433146 0.89 LMNA (0.47) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL4433144 0.89 LMNA (0.47) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL18783983 0.89 LMNA (0.47) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL3683341 0.85 LMNA (0.66) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL10989214 0.85 LMNA (0.66) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL2219671 0.85 LMNA (0.66) LMNATSHRCYP1A2CYP2C19TDP1
SCHEMBL6439369 0.85 LMNA (0.66) LMNATSHRCYP1A2CYP2C19TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1783111-B1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND SUMITOMO CHEMICAL CO (JP) 2015-04-08 EP disclosed
EP-2781522-A1 OPTICALLY ACTIVE BISOXAZOLINE COMPOUND, ASYMMETRIC CATALYST, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANE COMPOUND USING SAID CATALYST Sumitomo Chemical Company, Limited (JP) 2014-09-24 EP disclosed
EP-1607136-B1 OPTICALLY ACTIVE COPPER CATALYST COMPOSITION SUMITOMO CHEMICAL CO (JP) 2012-05-23 EP disclosed
EP-1593674-B1 OPTICALLY ACTIVE BISOXAZOLINE COMPOUNDS, PROCESS FOR PRODUCTION OF THE SAME AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2011-07-20 EP disclosed
US-7709651-B2 asymmetriccomplex of copper(I) trifluoromethanesulfonate and 1,1-bis[2-[(4S)-(tert-butyl)-oxazoline]]cyclopropane is added to 3-methyl-2-butenyl acetate and ethyl diazoacetate using dichloroethane solvent to effect reaction to produce ethyl 3,3-dimethyl-2-(acetoxymethyl)cyclopropanecarboxylate SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-05-04 US disclosed
US-7705165-B2 Method for producing optically active cyclopropanecarboxylate compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-27 US disclosed
US-7683215-B2 Optically active bisoxazoline compounds, process for production of the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-23 US disclosed
US-7671210-B2 Process for production of optically active cyclopropanecarboxylate compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-02 US disclosed
US-7671213-B2 Optically active bisoxazoline compounds, process for production of the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-02 US disclosed
EP-1783130-B1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND SUMITOMO CHEMICAL CO (JP) 2009-12-30 EP disclosed
EP-1783111-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
EP-1783130-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
US-20070032659-A1 Process for producing optically active cyclopropane compound and asymmetric copper complex for use in the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-02-08 US disclosed
US-20060211879-A1 Optically active copper catalyst composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-21 US disclosed
US-20060149077-A1 Optically active bisoxazoline compounds, process for production of the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-07-06 US disclosed
EP-1674445-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANE COMPOUND AND ASYMMETRIC COPPER COMPLEX FOR USE IN THE SAME Sumitomo Chemical Company, Limited (JP) 2006-06-28 EP disclosed
EP-1607136-A1 OPTICALLY ACTIVE COPPER CATALYST COMPOSITION Sumitomo Chemical Company, Limited (JP) 2005-12-21 EP disclosed
EP-1593674-A1 OPTICALLY ACTIVE BISOXAZOLINE COMPOUNDS, PROCESS FOR PRODUCTION OF THE SAME AND USE THEREOF Sumitomo Chemical Company, Limited (JP) 2005-11-09 EP disclosed
US-6207429-B1 REACTING 2,2-DIMETHYL-3-(SUBSTITUTED VINYL)CYCLOPROPANE-1-CARBOXYLIC ACID C1-C4 ESTERS WITH STEREOSPECIFIC ESTERASE FROM ARTHROBACTER TO FORM TRANS-2,2-DIMETHYL-3-(SUBSTITUTED VINYL)CYCLOPROPANE-1-CARBOXYLIC ACID SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-03-27 US disclosed
EP-0959139-A1 Method for producing optically active cyclopropanecarboxylic acid SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060149077-A1 Optically active bisoxazoline compounds, process for production of the same and use thereof ACSL3, ADSL, SQLE LMNA 2541/4885TSHR 3816/4885CYP1A2 25/4885
US-20070032659-A1 Process for producing optically active cyclopropane compound and asymmetric copper complex for use in the same CBR3, AOC3, CBR1 LMNA 4237/4885TSHR 397/4885CYP1A2 57/4885
US-20060211879-A1 Optically active copper catalyst composition CCNL2, HACL2, ARL1 LMNA 2648/4885TSHR 2249/4885CYP1A2 893/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.