Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091293 | 0.91 | MAPT (0.42) | MTORKIF11PIK3CAPIK3CGNAMPT | |
| SCHEMBL8099749 | 0.89 | MTOR (0.40) | MTORPIK3CAPIK3CGNAMPTKMT2A | |
| SCHEMBL8083200 | 0.89 | ALDH1A1 (0.43) | MTORKIF11PIK3CAPIK3CGNAMPT | |
| SCHEMBL8097966 | 0.87 | KIF11 (0.37) | MTORKIF11PIK3CAPIK3CGNAMPT | |
| SCHEMBL8092850 | 0.87 | CA12 (0.42) | MTORPIK3CAPIK3CGNAMPTPIK3CD | |
| SCHEMBL8099405 | 0.87 | EPHX1 (0.42) | MTORPIK3CANAMPTKDM4EMEN1 | |
| SCHEMBL8085029 | 0.86 | KIF11 (0.38) | MTORKIF11PIK3CAIKBKBCHUK | |
| SCHEMBL8090241 | 0.86 | NAMPT (0.43) | MTORPIK3CAPIK3CGNAMPTPIK3CD | |
| SCHEMBL8091026 | 0.85 | NAMPT (0.36) | MTORKIF11PIK3CANAMPTIKBKB | |
| SCHEMBL8084982 | 0.85 | KIF11 (0.38) | KIF11NAMPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |