Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846559 | 0.88 | — | — | |
| SCHEMBL8090133 | 0.85 | KDM4E (0.33) | GABRA1GABRA5KDM4EALDH1A1GAA | |
| SCHEMBL8091069 | 0.84 | TBXAS1 (0.36) | GABRA1GABRA5KDM4EALDH1A1GAA | |
| SCHEMBL8880656 | 0.83 | METAP1 (0.38) | GABRA1GABRA5KDM4EALDH1A1GAA | |
| SCHEMBL8880066 | 0.81 | HRH1 (0.43) | GABRA1GABRA5ALDH1A1MEN1MAPT | |
| SCHEMBL8880563 | 0.81 | GABRG2 (0.38) | GABRA1GABRA5KDM4EALDH1A1GAA | |
| SCHEMBL8881385 | 0.81 | GABRG2 (0.41) | GABRA1GABRA5KDM4EALDH1A1GAA | |
| SCHEMBL8097517 | 0.81 | KMT2A (0.43) | GABRA1GABRA5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8881176 | 0.81 | CYP19A1 (0.43) | GABRA1GABRA5KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8317441 | 0.79 | GABRA1 (0.41) | GABRA1GABRA5KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |