Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836007 | 0.85 | CHRNB2 (0.41) | KMT2AMAPK10ESR1MAPTALDH1A1 | |
| SCHEMBL8013343 | 0.80 | GAA (0.38) | MAPTALDH1A1KDM4ERAB9AGABRA2 | |
| SCHEMBL8100183 | 0.79 | GAA (0.36) | KMT2AMEN1MAPK1TP53GABRA2 | |
| SCHEMBL8098030 | 0.79 | ADORA2A (0.40) | KMT2AMAPK10ESR1MAPTALDH1A1 | |
| SCHEMBL8649980 | 0.78 | GABRA2 (0.45) | KMT2AMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL8099222 | 0.78 | GAA (0.38) | MAPTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL8098047 | 0.78 | GAA (0.36) | KMT2AALDH1A1MEN1KDM4EGABRA2 | |
| SCHEMBL7820269 | 0.78 | P2RY12 (0.37) | KMT2AMEN1 | |
| SCHEMBL8098246 | 0.77 | GAA (0.38) | MAPTALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL8011792 | 0.77 | GAA (0.36) | MAPTALDH1A1HPGDKDM4EGABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |