SCHEMBL8091036

SCHEMBL8091036

COc1ccc(CCCCCN2CCC(c3ccccc3)CC2)cc1

nearest known ligand 0.88

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 5/20 0.76
MEN1 O00255 1/20 0.73
TP53 P04637 1/20 0.73
CYP1A2 P05177 1/20 0.73
CYP3A4 P08684 1/20 0.73
CYP2D6 P10635 1/20 0.73
TSHR P16473 1/20 0.73
CYP2C19 P33261 1/20 0.73
KMT2A Q03164 1/20 0.73
DRD2 P14416 1/20 0.58
KCNA3 P22001 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7402939 0.94 SIGMAR1 (0.75) SIGMAR1MEN1TP53CYP1A2CYP3A4
SCHEMBL9373391 0.87 SIGMAR1 (1.00) SIGMAR1MEN1TP53CYP1A2CYP3A4
SCHEMBL866873 0.85 SIGMAR1 (1.00) SIGMAR1MEN1TP53CYP1A2CYP3A4
SCHEMBL8099058 0.83 SIGMAR1 (0.82) SIGMAR1MEN1TP53CYP1A2CYP3A4
SCHEMBL7319920 0.81 SIGMAR1 (0.69) SIGMAR1MEN1TP53CYP1A2CYP3A4
SCHEMBL9521523 0.81 SIGMAR1 (1.00) SIGMAR1MEN1TP53CYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7310794 0.81 SIGMAR1 (0.67) SIGMAR1MEN1TP53CYP1A2CYP3A4
SCHEMBL7375551 0.80 ALDH1A1 (0.59) SIGMAR1DRD2
Hydrochloric Acid SCHEMBL8054053 0.79 ALDH1A1 (0.58) SIGMAR1DRD2
SCHEMBL8092966 0.79 ALDH1A1 (0.64) SIGMAR1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US claimed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed